Optimize outcomes for FESS and balloon sinuplasty
Protect surgical outcomes, reduce symptoms and improve patient QoL3,4 by adding NEUROMARK® to FESS and balloon sinuplasty procedures.
Many Patients with Chronic Rhinosinusitis(CRS) also suffer from Chronic Rhinitis (CR) 2
While FESS and balloon sinuplasty relieve obstruction, these procedures do not address the root cause of inflammation caused by overactive nerves.
NEUROMARK is an innovative, clinically proven procedure designed to safely target overactive posterior nasal nerves (PNN) using low-power energy, providing durable relief from persistent symptoms.
At least 40% of CRS patients still have uncontrolled symptoms 3-5 years after surgery 3
NEUROMARK has shown significant symptom improvement for the symptoms that uncontrolled endoscopic sinus surgery patients report, including rhinorrhea, congestion, and postnasal drip. 4
When to consider adding NEUROMARK
NEUROMARK may be appropriate in patients whose symptoms are not fully explained or resolved by standard sinus interventions.
Drainage or rhinorrhea are dominant complaints
Persistent congestion drives symptoms despite
appropriate sinus intervention
Symptoms feel out of proportion to CT findings
Revision surgery is planned and residual disease
doesn’t explain symptoms
Symptoms respond to ipratropium but recur when
treatment stops
“Knowing that my patients can stand up and walk out and set up their follow up appointment, I find that to be very nice.”*
“The feedback and impedance value provide reassurance that you’re treating the right area effectively and thoroughly, ensuring each treatment delivers the intended result.”*
“It’s important to know that the system is delivering controlled RF energy to treat Chronic Rhinitis at the source.”*
Typical Patient Stories
NEUROMARK may be appropriate in patients whose symptoms are not fully explained or resolved by standard sinus interventions.
Longstanding CRS
Failed meds, sprays, allergy management
Scheduled for FESS or balloon
POSSIBLE COMPLAINTS
“Postnasal drip is the worst part."
"Congestion and mucus never stop."
Sinus surgery restores airflow and drainage pathways
Mucus and congestion may persist
Risk of "good surgery, unhappy patient"
Drainage and congestion may be driven by overactive posterior nasal nerves
Planning PNN up front may help address
rhinitis-related symptoms that can persist after surgery
Low-risk adjunct during an already planned surgical event
Deviated septum with turbinate hypertrophy
Constant congestion/runny nose
Often failed topical therapies
POSSIBLE COMPLAINTS
“I can’t breathe”
“I’m always stuffed up”
Septoplasty/turbinate reduction improves airflow
Mucus production and congestion may persist
Patient may breathe better but still feel symptomatic
Targets rhinitis-related symptoms driven by overactive posterior nasal nerves
Complements turbinate reduction by addressing a different contributor to symptoms
Aligns surgical plan with patient expectations
Balloon candidate or limited ESS
CT does not fully explain symptoms
Often labeled “sinus,” but behaves like rhinitis
POSSIBLE COMPLAINTS
“I’m always congested/runny”
“I drip all the time”
Structural intervention alone may notresolve symptoms
High likelihood of rhinitis-driven complaints
Opportunity to address both anatomy andneural input
Targets rhinitis-related symptoms driven by overactive posterior nasal nerves
Complements balloon sinus procedures by addressing neural contributors to symptoms
Planning together may help avoid
second-procedure conversations
What People Are Saying
“Day of the procedure, everything went smoothly and I was able to get back to my life with no impact.”
“The NEUROMARK procedure was very comfortable–not at all painful or disruptive. My symptoms improved over time, and today they are reduced at least 95%.”
“It’s based upon smart technology, the NEUROMARK device telling me that I have delivered adequate therapy to accomplish treatment”
“Day of the procedure, everything went smoothly and I was able to get back to my life with no impact.”
“The NEUROMARK procedure was very comfortable–not at all painful or disruptive. My symptoms improved over time, and today they are reduced at least 95%.”
“Day of the procedure, everything went smoothly and I was able to get back to my life with no impact.”
“The NEUROMARK procedure was very comfortable–not at all painful or disruptive. My symptoms improved over time, and today they are reduced at least 95%.”
“It’s based upon smart technology, the NEUROMARK device telling me that I have delivered adequate therapy to accomplish treatment”
Complete implementation support
NEURENT provides end-to-end support, including reimbursement guidance, facility adoption, and onboarding and training—helping you successfully implement NEUROMARK with confidence.
Frequently Asked Questions
If you don't see what you are looking for here, reach out to your healthcare provider or find a provider.
The NEUROMARK System uses propriety ENTelligent technology™ to target the overactive posterior nasal nerves (PNN) that cause the symptoms of Chronic Rhinitis. NEUROMARK utilizes controlled low-energy radiofrequency (RF) to create precise micro-lesions at target sites.
The CLARITY clinical study shows statistically significant and clinically meaningful symptom improvements in patients who receive NEUROMARK, with an 80% responder rate for reflective Total Nasal Symptom Score (rTNSS) as defined by a 30% reduction from baseline at 12 months.
NEUROMARK is an option for both long-term and newly diagnosed allergic and nonallergic Chronic Rhinitis patients. In the PARAGON 6-month clinical study, both allergic and nonallergic subgroups experienced significant improvement in all study outcome measures (p<.001) with no significant differences between subgroups.¹²
Unlike medication, which requires compliance to a regular schedule¹⁰, or surgery, which can be invasive and has a long recovery period, NEUROMARK treats symptoms directly at the source in a gentle, minimally invasive procedure.
Patients with common symptoms of Chronic Rhinitis such as excessive sneezing, rhinorrhea, postnasal drip, or frequent congestion may be good candidates for treatment. By recognizing these symptoms right away, you can help treat the source with NEUROMARK.
MyMark™ reimbursement and support services are available to provide you with everything you need when it comes to reimbursement support, from prior authorization and appeals support to case updates and billing inquiries. Talk to your local Area Sales Manager to learn more about MyMark.
*Testimonial reflects user experience and opinion of an actual patient. Individual results may vary.
**Reflective Total Nasal Symptom Score.
†Mini Rhinoconjunctivitis Quality of Life Questionnaire.
References:
.Yen DM, Davis GE, Ow RA, O’Malley EM, Del Signore AG. Two-year clinical outcomes after multipoint impedance-controlled radiofrequency ablation of the posterior nasal nerve for treatment of chronic rhinitis. Ear, Nose & Throat Journal. Published online October 9, 2025. doi:10.1177/01455613251382759
Nuutinen M, Lyly A, Virkkula P, et al. The relative proportion of comorbidities among rhinitis and rhinosinusitis patients and their impact on visit burden. Clin Transl Allergy. 2022;12(7):e12181. Published 2022 Jul 21. doi:10.1002/clt2.12181
van der Veen J, Seys SF, Timmermans M, Levie P, Jorissen M, Fokkens WJ, Hellings PW. Real-life study showing uncontrolled rhinosinusitis after sinus surgery in a tertiary referral centre. Allergy 2017; 72: 282–290
Smith TL, Schlosser RJ, Mace JC, et al. Long-term outcomes of endoscopic sinus surgery in the management of adult chronic rhinosinusitis. International Forum of Allergy & Rhinology. 2019;9(8):831-841. doi:10.1002/alr.22369. 5. Reh DD, Lay K, Davis G, et al. Long-term outcomes follow ing impedance-controlled radiofrequency ablation for the treatment of chronic rhinitis. Laryngoscope Investig Otolaryngol. 2024;9(3):e1286. Published 2024 Jun 4. doi:10.1002/lio2.1286.
The NEUROMARK® System is indicated for use in otorhinolaryngology (ENT) surgery for creation of radiofrequency (RF) lesions to disrupt posterior nasal nerves in patients with chronic rhinitis.
Please see Instructions for Use (IFU) for a complete listing of warnings, precautions, and adverse events.
CAUTION: Federal (USA) law restricts this device to sale by or on the order of a physician.