NEUROMARK®: Experience the Difference
NEUROMARK is the only system powered by ENTelligent™, a proprietary suite of advanced technologies that maximizes CONTROL to reach posterior nasal nerves and provides feedback to CONFIRM treatment delivery so you can treat a broad range of Chronic Rhinitis (CR) patients with CONFIDENCE.

Recognize the Symptoms. Treat the Source.
CR affects millions of patients in the US and is known to adversely impact sleep, cognitive function, and ultimately, quality of life and overall productivity.² By identifying the symptoms of CR, patients can seek effective relief and providers can address the root cause with the innovative NEUROMARK System.

A Prevalent Condition with Wide-Ranging Impact
CR is a global public health issue. Its high prevalence adversely affects sleep, cognitive function, mood, and overall performance at work or school.¹

Increased Risk of Comorbidities
Patients with CR are 1.5 to 4.5 times more likely to suffer from comorbid conditions such as asthma, eczema, migraines, and depression. Early identification can help mitigate these additional health risks.²

Significant Productivity Loss
Individuals with CR experience significantly higher productivity loss compared to those with other chronic conditions.³ This loss affects not only the individual but also workplaces and economies.

Daily Life Impairment
An overwhelming 80% of patients with moderate-to-severe rhinitis report impairment in their daily activities. Recognizing these symptoms allows you to intervene effectively and improve patient outcomes.⁴
Experience the Difference
NEUROMARK offers a cutting-edge approach to treating Chronic Rhinitis, combining precision engineering and advanced technology, with a focus on patient safety and comfort.

during TREATMENT
NEUROMARK features a flexible shaft and atraumatic leaflets that conform to patient anatomy, maximizing access to nerve-rich areas and allowing posterior placement.
The device provides maximal treatment coverage by targeting numerous microablation sites across a wide area. This ensures effective disruption of overactive posterior nasal nerve pathways while preserving mucosal and vascular integrity.5-7
ENERGY DELIVERY
Real-time apposition confirmation helps guide leaflet placement with immediate visual feedback.
NEUROMARK delivers gentle radiofrequency energy to disrupt posterior nasal nerve pathways while maintaining mucosal and vascular integrity.6-8
Impedance thresholds are monitored individually for each leaflet, with biofeedback confirming treatment is delivered adequately and discontinued at the optimal time.5
IN OUTCOMES
The CLARITY clinical study showed statistically significant and clinically meaningful improvements in CR symptoms following treatment with NEUROMARK.11
No serious adverse events or post-procedure “ice cream headaches” was 4.4 (0-10 scale) as reported, and the mean discomfort during the procedure were reported in the CLARITY Clinical Study.5
91%
80%
86%
Sinonasal Symptoms:
Causes & Treatments
Identify the cause to determine the best treatment option.
Differeniate with NEUROMARK
Learn how NEUROMARK is helping ENT specialists elevate patient care for Chronic Rhinitis.
Frequently Asked Questions
If you don't see what you are looking for here, reach out to your healthcare provider or find a provider.
The NEUROMARK System uses propriety ENTelligent technology™ to target the overactive posterior nasal nerves (PNN) that cause the symptoms of Chronic Rhinitis. NEUROMARK utilizes controlled low-energy radiofrequency (RF) to create precise micro-lesions at target sites.
The CLARITY clinical study shows statistically significant and clinically meaningful symptom improvements in patients who receive NEUROMARK, with an 80% responder rate for reflective Total Nasal Symptom Score (rTNSS) as defined by a 30% reduction from baseline at 12 months.
NEUROMARK is an option for both long-term and newly diagnosed allergic and nonallergic Chronic Rhinitis patients. In the PARAGON 6-month clinical study, both allergic and nonallergic subgroups experienced significant improvement in all study outcome measures (p<.001) with no significant differences between subgroups.¹⁰
Unlike medication, which requires compliance to a regular schedule¹¹, or surgery, which can be invasive and has a long recovery period, NEUROMARK treats symptoms directly at the source in a gentle, minimally invasive procedure.
Patients with common symptoms of Chronic Rhinitis such as excessive sneezing, rhinorrhea, postnasal drip, or frequent congestion may be good candidates for treatment. By recognizing these symptoms right away, you can help treat the source with NEUROMARK.
MyMark™ reimbursement and support services are available to provide you with everything you need when it comes to reimbursement support, from prior authorization and appeals support to case updates and billing inquiries. Talk to your local Area Sales Manager to learn more about MyMark.
See the difference NEUROMARK can make in your practice.
Talk to a Neurent Medical sales representative today to learn how NEUROMARK can help you help more patients.
*Testimonial reflects user experience and opinion of an actual patient. Individual results may vary.
**Reflective Total Nasal Symptom Score.
†Mini Rhinoconjunctivitis Quality of Life Questionnaire.
References:
Vandenplas O, Vinnikov D, Blanc PD, et al. Impact of Rhinitis on Work Productivity: A Systematic Review. J Allergy Clin Immunol Pract. 2018;6(4):1274-1286.e9. doi:10.1016/j.jaip.2017.09.002.
Derebery, J., Meltzer, E., Nathan, R. A., et al. (2008). Rhinitis symptoms and comorbidities in the United States: Burden of rhinitis in America survey. Otolaryngology–Head and Neck Surgery, 139(2), 198–205. h.ps://doi.org/10.1016/j.otohns.2008.05.019.
Lamb CE, Ratner PH, Johnson CE, Ambegaonkar AJ, Joshi AV, Day D, et al. Economic impact of workplace productivity losses due to allergic rhinitis compared with select medical conditions in the United States from an employer perspective. Current medical research and opinion 2006;22:1203-10.
Ozdoganoglu T, Songu M, Inancli HM. Quali. of life in allergic rhinitis. Ther Adv Respir Dis. 2012;6(1):25-39. doi:10.1177/1753465811424425.
Reh, DD, Lay KL, Davis G, et al. Clinical evaluation of a novel multipoint radiofrequency ablation device to treat chronic rhinitis. Laryngoscope Investig Otolaryngol. 2023. Published online 16 March 2023:DOI: 10.1002/lio2.1040
TR-018 In vivo assessment of radiofrequency ablation for nasal tissue ablation in an in vivo porcine model-2019.
Haveman J, Van Der Zee J, Wondergem J, Hoogeveen JF, Hulshof MC. Effects of hyperthermia on the peripheral nervous system: a review. Int J Hyperthermia. 2004;20(4):371-391.
Hsu M. Significance of clinical treatments on peripheral nerve and its effect on nerve regeneration. Journal of Neurological Disorders. 2014;02(04). doi:10.4172/2329-6895.1000168.
Davis GE, Ow RA, Yen DM, O'Malley EM, Del Signore AG. Clinical Outcomes After Innovative Multipoint Impedance-Controlled Radiofrequency Ablation of the Posterior Nasal Nerve for Treatment of Chronic Rhinitis. Ear Nose Throat J. Published online September 24, 2024. doi:10.1177/01455613241285134.
Greiwe JC, Bernstein JA. Combination therapy in allergic rhinitis: What works and what does not work. Am J Rhinol Allergy. 2016;30(6):391-396. doi:10.2500/ajra.2016.30.4391
Reh DD, Lay K, Davis G, et al. Long-term outcomes follow ing impedance-controlled radiofrequency ablation for the treatment of chronic rhinitis. Laryngoscope Investig Otolaryngol. 2024;9(3):e1286. Published 2024 Jun 4. doi:10.1002/lio2.1286.
The NEUROMARK® System is indicated for use in otorhinolaryngology (ENT) surgery for creation of radiofrequency (RF) lesions to disrupt posterior nasal nerves in patients with chronic rhinitis.
Please see Instructions for Use (IFU) for a complete listing of warnings, precautions, and adverse events.
CAUTION: Federal (USA) law restricts this device to sale by or on the order of a physician.